γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation

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γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation

BACKGROUND The histone variant histone H2A.X comprises up to 25% of the H2A complement in mammalian cells. It is rapidly phosphorylated following exposure of cells to double-strand break (DSB) inducing agents such as ionising radiation. Within minutes of DSB generation, H2AX molecules are phosphorylated in large chromatin domains flanking DNA double-strand breaks (DSBs); these domains can be ob...

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s from the 1 European Congress of Medical Physics September 1–4, 2016 Eugenides Foundation, Athens, Greece

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Macrophages are potent elicitors of inflammatory cytokines and nitric oxide (NO). As such, they have been associated with side effects of therapeutic irradiation including pneumonitis and skin fibrosis. While several studies have addressed the effects of X-rays or gamma rays on macrophages, virtually no work has been carried out to date concerning the effects of heavy ion radiation on these cel...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2007

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0001057